Possible Interaction: Eicosapentaenoic Acid and Phospholipids

“However, in rats and humans, we have found that low doses of EPA actually elevate membrane AA phospholipid concentrations.”

“Supplementation with EPA significantly increased the proportion of EPA in the plasma CE and PL fractions, (both by 2.7-fold, day 4 and day 7) and in the RBC PL (by 1.9-fold, day 4 and day 7).”

“Plasma phospholipid EPA levels increased significantly (P <0.0001) after supplementation with EPA , and DHA composition increased with DHA supplementation (P <0.0001).”

“The proportion of EPA in PL showed a 15-fold increase after 7 d (P < 0.001), while DHA showed a smaller increase (P < 0.01).”

“ EPA levels increased in serum phospholipid by 117% (from …/100 g fatty acids) and in platelet phospholipid by 176% (0.21 to 0.58 g/100 g fatty acids) via metabolic retroconversion; the … to EPA was 11.3 and 12.0%, based on the serum and platelet analyses, respectively.”

“ EPA concentrations increased by 2.5-fold in the plasma lipid fractions and neutrophil phospholipids.”

“First, EPA and DHA may compete for residency in membrane phospholipids and thereby differentially displace n-6 PUFAs, which are highly prevalent in the Western diet.”

“Our results also exhibited that treatment with 1 mM liposomes composed of SFP or SCP for 3 h tended to increase the EPA content in phospholipid fractions of both differentiated Caco-2 and M cells.”

“This effect is apparently due to the incorporation of eicosapentaenoic acid in membrane phospholipids.”

“Small human trials confirmed that supplementation with eicosapentaenoic acid results in increased eicosapentaenoic acid in phospholipids and decreased generation of leukotrienes by neutrophils.”