Possible Interaction: Eicosapentaenoic Acid and Palmitic Acid

“Likewise, PA and EPA have opposing effects in terms of actin polymerization.”

“The influence of palmitic acid on fibroblasts was inhibited by eicosapentaenoic acid (EPA), an inhibitor of Toll-like receptors (TLRs).”

“Using this novel experimental system, we show that DHA and EPA have inhibitory effects on the uptake of PA and AA by PC-3 cells.”

“In addition, EPA , ACSL3 siRNA and ACS inhibitor attenuated calcium deposition and caspase activation induced by PA.”

“In this study, we tested the hypothesis that EPA prevents the osteoblastic differentiation and mineralization of vascular smooth muscle cells (VSMC) induced by palmitic acid (PA), the most abundant long-chain saturated fatty acid in plasma.”

“ PA increased and EPA abolished the expression of the genes for bone-related proteins, including bone morphogenetic protein (BMP)-2, Msx2 and osteopontin in human aortic smooth muscle cells (HASMC).”

“These results identify ACSL3 and NF-κB as mediators of PA-induced osteoblastic differentiation and calcium deposition in VSMC and suggest that EPA prevents vascular calcification by inhibiting such a new molecular pathway elicited by PA.”

“ Eicosapentaenoic acid (20:5omega3) had the strongest effect against palmitic acid on TG.”

“Finally, PAM elevated the expressions of autophagy-related proteins (LC3I, LC3II, p62) and mitochondrial fission protein (Drp1), whereas EPA inhibited their elevation under PAM treatment.”

“In contrast, eicosapentaenoic acid dose-dependently abrogated effects of LPS or palmitic acid on increasing EL expression.”

“ EPA administration significantly decreased cardiac levels of palmitic , oleic, and linoleic acids in the HC diet groups.”

“The fatty acyl-CoA oxidase activity was greater in rats treated with EPA for 15 days and palmitic acid for 10 days compared to control.”

“The rate of eicosapentaenoic acid elongation in the fed state was 50% higher than using palmitic acid as a substrate.”