Possible Interaction: Eicosapentaenoic Acid and Norepinephrine

“ Eicosapentaenoic and docosahexaenoic acids (Ω-3 series) impaired the synthesis and release of both NA and AD.”

“Since EPA has been found to antagonize noradrenaline (NA) — induced vasoconstriction, the influences on bleeding time of the α-receptor antagonist phentolamine and of the adrenergic neuron blocking agent guanethidine alone as well as during dietary supplementation with MaxEPA were studied.”

“Emax of NA was reduced in particular at the highest concentration of EPA.”

“In the presence of indomethacin the levels of both PGs were below the detection limits of the radioimmunoassay.9.Conclusion: The results show that EPA is able to reduce the vasoconstriction induced by NA and A II in peripheral small vessels of the rabbit.”

“In the presence of extracellular Ca2+, EPA induced significant relaxations at >10 micromol/L (P<.01) in norepinephrine (NE) (10(-6) mol/L)-contracted aortic rings and at 30 micromol/L (P<.001) in high K+ (80 mmol/L)-contracted aortic rings.”

“In a second experiment bleeding time and mesenteric vascular reactivity to noradrenaline were increased 2-4 weeks after receiving a moderate intake of EPA and these effects persisted 5-21 d after switching to a control diet.”

“Pretreatment with eicosapentaenoic (10 microM) or docosahexaenoic acids (1-10 microM) decreased the contractile response to physiologic concentrations of norepinephrine.”

“ Eicosapentaenoic acid (EPA) dose-dependently antagonized the effect of NPY to a similar degree as that of NA.”

“Moreover, EPA (33 mumol/l) diminished the combined vasoconstrictor effect of NA and NPY.”

“Vascular response to norepinephrine was enhanced by EPA vs. DUM and OL, whereas the response to angiotensin was similar in EPA and DUM groups, but reduced by OL.”

“Thus, the contractile effect of norepinephrine in isolated rat aortic strips is normally augmented by intrinsic prostaglandins, and this augmentation is diminished by dietary intake of EPA.”