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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Eicosapentaenoic Acid
drug:
Nitrendipine
Research Papers that Mention the Interaction
“Kinetic studies further revealed that both AA and EPA enhanced the off rate of [3H]nitrendipine binding.”
“Scatchard analyses of [3H]nitrendipine (dihydropyridine) binding to cardiac membranes in the presence of AA or EPA resulted in a decrease in the KD (-1/slope) with no effect on Bmax (x intercept).”
Bay K 8644 is a Negative Inotrope in the Presence of Arachidonic Acid but not Eicosapentaenoic Acid“ EPA or DHA (5 microM) blocks the inhibitory effects of nitrendipine but not those of verapamil or diltiazem.”
“Specific binding of [3H]nitrendipine to intact myocytes is noncompetitively inhibited by EPA or DHA in a manner that reduces the number of high- and low-affinity binding sites (Bmax) and increases their affinities.”
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