Possible Interaction: Eicosapentaenoic Acid and Linolenic Acid

“Compared to our previous study, where we simply increased the ALA intake, our results show that ALA supplementation combined with a reduced LA intake (loLA/hiALA diet) more efficiently enhanced EPA blood concentrations.”

“We previously reported a >50% increase in mean plasma eicosapentaenoic acid levels in a general medicine clinic population after supplementation with α-linolenic acid.”

“ ALNA supplementation increased the proportion of EPA but not DHA in plasma phospholipids.”

“The optimal dose of n-3 is not yet determined, but prospective … suggest that the addition of 0.5-1.8 grams/day of marine-derived eicosapentaenoic acid and docosahexaenoic … plant derived alpha-linolenic acid at a dose of 1.5-3 … significantly reduce subsequent cardiac events and mortality.”

“…,eicosapentaenoic acid (… ( ALA ) were higher in AN than in controls (lauric acid: 15,081.6 ± 14,970.2 vs. 8257.4 ± 4740.2 pmol/mL; ALA …/mL; DPA: 32,664.8 ± 16,215.0 vs. 20,969.0 ± 12,350.0 pmol/mL. FDR-adjusted p-values < 0.05).”

“Moderate intake of LA/ALA ratio may reduce plasma concentration of EPA in pregnants carrying the rs174575 minor allele.”

“The increase in ALA and DHA, as well as the conversion of ALA to EPA is attributed to the supplementation of sufficient amounts of ALA and DHA, respectively.”

“Short-term dietary supplementation with alpha-linolenic acid increases the proportion of eicosapentaenoic acid (20:5n-3) but does not increase the proportion of DHA in blood lipids.”

“ ALA or GLA given as single supplements did not increase LCP omega 3 status, but their combination augmented LCP omega 3 (in CE) and EPA (in fasting TG) to a statistically significant, but nevertheless negligible, extent.”

“Among vegetarians and persons who consume low amounts of linoleic acid (C 18:2n-6 ), dietary intake of alphalinolenic acid (C 18:3n-3 ) from other foods such as tofu, soybean oil, and canola oil may increase cell membrane levels of EPA.”