Possible Interaction: Eicosapentaenoic Acid and Leukotriene C4

“In … EPA, … LTC4 increased a little but significant (p < 0.05) to 85.3 +/- 24.2 ng/10(7) cells at low dose (1 microgram/ml) …, and then decreased to 39.7 +/- 23.4 ng/10(7) cells at high dose (30 micrograms/ml) of EPA (p < 0.05).”

“Total LTC LTC4 + LTC5) generation with high dose of EPA (57.2 +/- 28.0 ng/10(7) cells) decreased significantly compared with that in the absence of fatty acids (78.2 +/- 25.4 ng/10(7) cells).”

“In the presence of EPA , the amount of LTC4 generated rose to peak at 16.5 +/- 1.9 ng/10(6) eosinophils at 10 micrograms/ml EPA and then fell to 8.3 +/- 3.1 ng/10(6) cells at 40 micrograms/ml EPA.”

“In non-… parenchymal strips EPA inhibited the myotropic activity of … as histamine (9 gmol/1), LTC4 (16 nmol/1) and the TX mimetic U 46619 (28.4 nmol/1), an effect which was … indomethacin (2.8 gmol/1) nor by the lipoxygenase inhibitor nordihydroguaiaretic acid (NDGA, 10 gmol/1).”

“The eicosapentaenoic acid pretreatment also potentiated cell migration activity in response to several other chemotactic factors such as basic fibroblast growth factor, tumor necrosis factor-alpha and leukotriene C4.”

“ EPA suppresses LTC4- and D4-induced contractions of guinea-pig tracheal smooth muscle through a 5-lipoxygenase pathway.”

“Coronary vasoconstriction elicited by infusion of exogenous LTC4 (20 × 10−12 mol min−1) was dose‐dependently inhibited by infusions of EPA.”