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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Eicosapentaenoic Acid
drug:
Leukotriene B4
Research Papers that Mention the Interaction
“ EPA and DHA were negatively correlated with LPS-induced TNFα, IL-8, LTB4 , TxB2, and TF in whole blood.”
“The levels of leukotriene B4 , thromboxane A2, and prostaglandin I2 were significantly lower in patients receiving EPA than in those not receiving it (all P < 0.01).”
“Pretreatment of PMNs with either EPA or DHA reduced the receptor expression for both FMLP and LTB4.”
“The stimulated [Ca2+]i by either FMLP or LTB4 was suppressed in a high Ca2+ environment after pretreatment with either EPA or DHA but not with OA or LA.”
“BACKGROUND Enteral nutrition containing eicosapentaenoic (20:5 omega-3) and gamma-linolenic acid (18:3 omega-6) decreases leukotriene B4 levels and neutrophils in bronchoalveolar lavage fluid of patients and animals with acute respiratory distress syndrome.”
Inhibition of 5-lipoxygenase induces cell death in anti-inflammatory fatty acid-treated HL-60 cells.“Added EPA (10 μ molL‐1) also suppressed 4‐series 5‐LOP and significantly reduced leukotriene B4 concentration by 48% from 39.9 ±3.2 to 20.6 ± 11.4 pmol L‐1 again with a concomittant increase of inactive 5‐series metabolites.”
“It has been demonstrated that both auranofin and eicosapentaenoic acid (EPA) have anti-inflammatory properties and both inhibit neutrophil leukotriene B4 (LTB4) synthesis.”
“The … EPA on monocyte function in …: (1) suppression of LTB4 synthesis concomitantly with that of the other 5-lipoxygenase pathway products and decreased [3H]-arachidonic acid release, (2) suppression of …, and (3) delayed kinetics of inhibition of PAF generation and AA metabolism relative to that of cellular lipid alteration.”
“ EPA decreased the production of leukotriene B4 (LTB4) and increased the formation of leukotriene B5 (LTB5) and 5-hydroxyeicosapentaenoic acid significantly in A23187-stimulated neutrophils.”
Long-term administration of highly purified eicosapentaenoic acid provides improvement of psoriasis.“ EPA and DHA, when released, inhibit cyclooxygenase and lipoxygenase and reduce eicosanoid synthesis, particularly thromboxane (TXA2) and leukotriene B4 (LTB4), by platelets and macrophages.”
“The dietary introduction of n-3 fatty acids, such as EPA , may reduce the epidermopoiesis and neutrophil migration evoked by LTB4 through decreases in generation of LTB4 and the capacity of LTB5 to inhibit the effects of LTB4.”
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