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Last Updated: 2 years ago

Possible Interaction: Eicosapentaenoic Acid and Leukotriene B4

Research Papers that Mention the Interaction

EPA and DHA were negatively correlated with LPS-induced TNFα, IL-8, LTB4 , TxB2, and TF in whole blood.
Lipids  •  2006  |  View Paper
The levels of leukotriene B4 , thromboxane A2, and prostaglandin I2 were significantly lower in patients receiving EPA than in those not receiving it (all P < 0.01).
Bone Marrow Transplantation  •  2001  |  View Paper
Pretreatment of PMNs with either EPA or DHA reduced the receptor expression for both FMLP and LTB4.
The stimulated [Ca2+]i by either FMLP or LTB4 was suppressed in a high Ca2+ environment after pretreatment with either EPA or DHA but not with OA or LA.
Inflammation  •  2004  |  View Paper
BACKGROUND Enteral nutrition containing eicosapentaenoic (20:5 omega-3) and gamma-linolenic acid (18:3 omega-6) decreases leukotriene B4 levels and neutrophils in bronchoalveolar lavage fluid of patients and animals with acute respiratory distress syndrome.
JPEN. Journal of parenteral and enteral nutrition  •  2004  |  View Paper
Added EPA (10 μ molL‐1) also suppressed 4‐series 5‐LOP and significantly reduced leukotriene B4 concentration by 48% from 39.9 ±3.2 to 20.6 ± 11.4 pmol L‐1 again with a concomittant increase of inactive 5‐series metabolites.
European journal of clinical investigation  •  1995  |  View Paper
It has been demonstrated that both auranofin and eicosapentaenoic acid (EPA) have anti-inflammatory properties and both inhibit neutrophil leukotriene B4 (LTB4) synthesis.
Biochemical pharmacology  •  1992  |  View Paper
The … EPA on monocyte function in …: (1) suppression of LTB4 synthesis concomitantly with that of the other 5-lipoxygenase pathway products and decreased [3H]-arachidonic acid release, (2) suppression of …, and (3) delayed kinetics of inhibition of PAF generation and AA metabolism relative to that of cellular lipid alteration.
World review of nutrition and dietetics  •  1991  |  View Paper
EPA decreased the production of leukotriene B4 (LTB4) and increased the formation of leukotriene B5 (LTB5) and 5-hydroxyeicosapentaenoic acid significantly in A23187-stimulated neutrophils.
Dermatologica  •  1991  |  View Paper
EPA and DHA, when released, inhibit cyclooxygenase and lipoxygenase and reduce eicosanoid synthesis, particularly thromboxane (TXA2) and leukotriene B4 (LTB4), by platelets and macrophages.
The American journal of clinical nutrition  •  1990  |  View Paper
The dietary introduction of n-3 fatty acids, such as EPA , may reduce the epidermopoiesis and neutrophil migration evoked by LTB4 through decreases in generation of LTB4 and the capacity of LTB5 to inhibit the effects of LTB4.
The Journal of investigative dermatology  •  1987  |  View Paper
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