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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Eicosapentaenoic Acid
drug:
Leptin
Research Papers that Mention the Interaction
“One mM of eicosapentaenoic acid or docosahexaenoic acid (DHA) reduced leptin expression by 71% and 78%, respectively, as compared with control, after 72 h. There was no effect on expression of the signal transducing form of the leptin receptor.”
Reduction of leptin gene expression by dietary polyunsaturated fatty acids.“For fish oil group there were significant correlations between leptin and weight loss (p = 0.01) and leptin and EPA and DHA (p < 0.05 for both).”
“In contrast, eicosapentaenoic acid at similar concentration decreased internalisation of leptin by 2-fold.”
“Interestingly, both EPA and DHA could inhibit cartilage damage induced by leptin plus IL1β by reducing the activation of NFκB and JNK, which led to the decrease of ADAMTS4 secretion.”
Leptin alone and in combination with interleukin-1-beta induced cartilage degradation potentially inhibited by EPA and DHA“Furthermore, EPA treatment increased leptin release from young cells, while DHA did not affect the secretion of this adipokine.”
“However, other studies have reported inhibitory effects of EPA on leptin expression and secretion in vivo and in vitro.”
“Together, the results suggest that EPA , like insulin, stimulates leptin production by increasing the nonanaerobic/oxidative metabolism of glucose.”
“ EPA caused a time- and dose-dependent increase of leptin mRNA levels in 3T3-L1 adipocytes.”
“These data suggest that EPA up-regulates leptin gene expression and its secretion probably through a hexosamine biosynthetic pathway.”
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