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Last Updated: 3 months ago

Possible Interaction: Eicosapentaenoic Acid and Interleukin-10

Research Papers that Mention the Interaction

Cytokines such as tumor necrosis factor-α, interferon-γ, and interleukin-10 were also significantly decreased by EPA (P < 0.05), as were factors causing vascular endothelial damage such as thrombomodulin and plasminogen activator inhibitor-1 (P < 0.05).
Bone Marrow Transplantation  •  2001  |  View Paper
IL-10 (P for trend = 0.023) and IL-6 (P for trend = 0.036) showed significantly positive association with the ratio of C20:4 n-6 and C20:5 n-3.
World journal of gastroenterology  •  2016  |  View Paper
Satoh-Asahara et al. (1) recently … with purified eicosapentaenoic acid EPA ; 1.8 g daily) for 3 months … EPA/arachidonic acid (AA) ratio and interleukin-10 levels of peripheral blood monocytes in association with slight decreases in the … velocity, an index of arterial stiffness, in obese patients with dyslipidemia.
Diabetes Care  •  2013  |  View Paper
CONCLUSIONS This study is the first to show that EPA increases the monocyte IL-10 expression in parallel with decrease of arterial stiffness, which may contribute to the antiatherogenic effect of EPA in obese dyslipidemic patients.
EPA significantly increased serum IL-10 and EPA levels, the EPA/arachidonic acid (AA) ratio, and monocyte IL-10 expression and decreased the pulse wave velocity (PWV), an index of arterial stiffness, compared with the control group.
Furthermore, EPA significantly increased the expression and secretion of IL-10 in human monocytic THP-1 cells through a peroxisome proliferator–activated receptor (PPAR)γ-dependent pathway.
Diabetes Care  •  2012  |  View Paper
The EPA group had a significantly (P < 0.05) attenuated stress response for TNFα, IL-10 , and IL-8 compared with the standard group.
Annals of surgery  •  2009  |  View Paper
The decrease in IL-2 and INF-gamma production was observed for both fatty acids, whereas the production of IL-10 was decreased by EPA only.
The Journal of nutritional biochemistry  •  2004  |  View Paper
EPA and DHA (25 μM) also decreased production of the key immunoregulatory cytokines IL-10 , TNF-α, and INF-γ.
Lipids  •  2004  |  View Paper
Content of IL-10 was significantly increased after EPA treatment.
Medical science monitor : international medical journal of experimental and clinical research  •  2018  |  View Paper
In contrast, dietary EPA increased the expression of these genes in Il10–/– mice.
Results: In this study, dietary EPA reversed the decrease in colon fatty acid β-oxidation gene expression observed in OA-fed Il10–/– compared to C57 mice.
Lifestyle Genomics  •  2008  |  View Paper
Significantly, EPA treatment enhanced hippocampal IL-10 concentration that was inversely correlated with IL-1β concentration.
Journal of Biological Chemistry  •  2003  |  View Paper
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