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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Eicosapentaenoic Acid
drug:
Interleukin-10
Research Papers that Mention the Interaction
“Cytokines such as tumor necrosis factor-α, interferon-γ, and interleukin-10 were also significantly decreased by EPA (P < 0.05), as were factors causing vascular endothelial damage such as thrombomodulin and plasminogen activator inhibitor-1 (P < 0.05).”
Oral eicosapentaenoic acid for complications of bone marrow transplantation“ IL-10 (P for trend = 0.023) and IL-6 (P for trend = 0.036) showed significantly positive association with the ratio of C20:4 n-6 and C20:5 n-3.”
“Satoh-Asahara et al. (1) recently … with purified eicosapentaenoic acid EPA ; 1.8 g daily) for 3 months … EPA/arachidonic acid (AA) ratio and interleukin-10 levels of peripheral blood monocytes in association with slight decreases in the … velocity, an index of arterial stiffness, in obese patients with dyslipidemia.”
“CONCLUSIONS This study is the first to show that EPA increases the monocyte IL-10 expression in parallel with decrease of arterial stiffness, which may contribute to the antiatherogenic effect of EPA in obese dyslipidemic patients.”
“ EPA significantly increased serum IL-10 and EPA levels, the EPA/arachidonic acid (AA) ratio, and monocyte IL-10 expression and decreased the pulse wave velocity (PWV), an index of arterial stiffness, compared with the control group.”
“Furthermore, EPA significantly increased the expression and secretion of IL-10 in human monocytic THP-1 cells through a peroxisome proliferator–activated receptor (PPAR)γ-dependent pathway.”
“The EPA group had a significantly (P < 0.05) attenuated stress response for TNFα, IL-10 , and IL-8 compared with the standard group.”
“The decrease in IL-2 and INF-gamma production was observed for both fatty acids, whereas the production of IL-10 was decreased by EPA only.”
“ EPA and DHA (25 μM) also decreased production of the key immunoregulatory cytokines IL-10 , TNF-α, and INF-γ.”
“Content of IL-10 was significantly increased after EPA treatment.”
Eicosapentaenoic Acid Improves Polycystic Ovary Syndrome in Rats via Sterol Regulatory Element-Binding Protein 1 (SREBP-1)/Toll-Like Receptor 4 (TLR4) Pathway“In contrast, dietary EPA increased the expression of these genes in Il10–/– mice.”
“Results: In this study, dietary EPA reversed the decrease in colon fatty acid β-oxidation gene expression observed in OA-fed Il10–/– compared to C57 mice.”
“Significantly, EPA treatment enhanced hippocampal IL-10 concentration that was inversely correlated with IL-1β concentration.”
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