Possible Interaction: Eicosapentaenoic Acid and Insulin

“Both EPA and DHA increased fasting insulin significantly.”

“Moreover, EPA and DHA may improve insulin sensitivity by generating proresolving lipid mediators and promoting alternatively activated macrophages.”

“ EPA , DHA and AA augment endothelial nitric oxide synthesis, potentiate insulin action both in the peripheral tissues and brain and alter leptin production.”

“ EPA treatment significantly reduced the levels of immunoreactive insulin , triglycerides, SAA–LDL, CRP, PWV and CAVI and increased the levels of adiponectin relative to the control group for 3 months (P<0.05).”

“Our results found that the concanavalin A and insulin increase significantly the proliferative response while eicosapentaenoic , arachidonic and docosahexaenoic acid inhibited that by different degrees: 47%, 37% and 19%, respectively, for healthy subjects and 39%, 29% and 13% for diabetes.”

“Basal glucose transport and oxidation (CO2) were increased 2-fold after EPA , and insulin (100 nM) stimulated glucose transport and oxidation similarly in control and EPA-treated myotubes, whereas these responses to insulin were abolished after OA treatment.”

“In addition, insulin (1 micromol/l) markedly increased ET-1 production, and EPA also significantly decreased the effect induced by insulin.”

“Exogenous administration of eicosapentaenoic acid (EPA) improves insulin sensitivity, but its precise mechanism remains unknown.”

“These findings raise the possibility that EPA up-regulates metabolic action of insulin and inhibits cell growth in humans.”

“ EPA and DHA supplementation (3.2% of total fat), in 6-month-old male, C57BL/6 mice fed HFD (60% fat) partially mitigated reductions in insulin sensitivity.”

“Furthermore, mice supplemented with EPA exhibited a higher insulin sensitivity (+24%) and glucose tolerance (+20%) compared with HF-fed mice.”