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Last Updated: 2 years ago

Possible Interaction: Eicosapentaenoic Acid and Icosapent Ethyl

Research Papers that Mention the Interaction

EPA-E increased EPA content more than threefold, without changing the quantities of arachidonic acid in serum lipids.
Nihon Kyobu Shikkan Gakkai zasshi  •  1995  |  View Paper
Icosapent ethyl increased EPA levels in plasma (+639%; p < 0.0001; n = 49) and red blood cells (+599%; p < 0.0001; n = 47) versus placebo.
Journal of women's health  •  2018  |  View Paper
The increase in EPA levels with increased IPE dose corresponded with the TG-lowering effect.
Prostaglandins, leukotrienes, and essential fatty acids  •  2013  |  View Paper
On administration of 1800 mg/day of IPA-E , the plasma level of IPA increased significantly, while the plasma level of DHLA decreased significantly, but no significant changes were observed in plasma DHA and AA concentrations.
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics  •  1993  |  View Paper
Furthermore, EPA-E feeding induced a significant decrease in the level of arachidonic acid and a significant increase in that of EPA in peritoneal macrophages.
Gastroenterology  •  1992  |  View Paper
In addition, the contents of EPA and docosapentaenoic acid (DPA) in macrophage phospholipids were dose dependently and significantly increased by EPA-E feeding.
Clinical biochemistry  •  1992  |  View Paper
ResultsIn plasma, treatment with icosapent ethyl 4 g/day resulted in significant increases versus placebo in the mean concentrations of EPA (+ 635%; P < 0.0001) and its metabolite, docosapentaenoic acid n-3 (+ 143%; P < 0.0001) with no significant change in docosahexaenoic acid.
Cardiology and Therapy  •  2019  |  View Paper