Possible Interaction: Eicosapentaenoic Acid and Docosahexaenoic Acid

“Conversely, the efficacy of EPA administered alone seemed to be greater in terms of risk reduction of MACE (-25%) or MI (-30%) than the combined EPA + DHA supplementation.”

“There was a positive association between age and EPA in PC, CE and TAG, DPA in NEFA and CE, and DHA in PC and CE (P≤0·034).”

“Consistency between years, at a location, was less for the high to low value ratio of EPA plus DHA than for the median value of EPA plus DHA.”

“The median level of EPA plus DHA differed dramatically between locations and sometimes between slaughters from the same location.”

“The ratio of EPA plus DHA from lambs with high values (97.5% quantile) to lambs with low values (2.5% quantile) also differed dramatically between locations, and between slaughters from the same location.”

“Nonetheless, the present evidence suggests that EPA and DHA have both shared and complementary benefits.”

“Increased oral intake of EPA and DHA modifies the content of arachidonic acid as well as of EPA and DHA.”

“… EPA … DHA could lower blood pressure in these patients and an inverse association between plasma PUFA content and blood pressure has been described.18–21 Dihomo-… of Biotechnology, Jawaharlal Nehru Technological University, Kakinada 533 003, India and UND Life Sciences, 13800 Fairhill Road, #321, Shaker Heights, OH 44120, USA.”

“ EPA and DHA inhibit AA metabolism.”

“A randomized double blind clinical trial with the new emulsion revealed rapid incorporatiom of EPA and DHA in cell membranes resulting in a considerably decreased AA/EPA ratio.”

“In conclusion, co-supplementation of PS and EPA + DHA could increase the effectiveness of treatment for hepatic steatosis.”

“Participants with a reduction >0·25 mmol/l after both DHA and EPA had higher non-HDL-cholesterol, TAG and insulin concentrations compared with other responders at baseline (all P < 0·05).”