Possible Interaction: Eicosapentaenoic Acid and Dinoprost

“Pretreatment with EPA and DHA resulted in a significant decrease in vascular reactivity induced by U46619 and PGF2α compared to NE.”

“ PGF2α changes correlated inversely with changes in plasma DHA and EPA.”

“Similarly, EPA exhibited significant inhibitory effects against the contractions induced by both U46619 and PGF2α without substantially affecting either PE- or high-KCl-induced contractions.”

“The inhibitory effect of EPA on PGF2alpha production was reverted in BEND cells treated with an increasing n-6-to-n-3 fatty acid ratio.”

“Both bIFN-τ and EPA inhibited secretion of PGF2α , and their inhibitory effects were additive.”

“The use of EPA and DHA to inhibit uterine secretion of PGF2α and to improve embryonic survival in cattle warrants further investigation.”

“The EPA and DHA inhibit secretion of PGF2α through a mechanism different from that of bIFN-τ.”

“The EPA inhibited secretion of PGF2α at 6.25 μM. Secretion of PGF2α in response to PDBu decreased with increasing incubation time with EPA.”

“Polyunsaturated fatty acids such … linoleic, linolenic, eicosapentaenoic and docosahexaenoic … may inhibit prostaglandin F2alpha synthesis through mechanisms such as decreased availability of its precursor arachidonic acid, an increased competition by these fatty … with arachidonic acid for binding to prostaglandin H synthase, and inhibition of prostaglandin H synthase synthesis and activity.”