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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Eicosapentaenoic Acid
drug:
Clopidogrel
Research Papers that Mention the Interaction
“In conclusion, EPA treatment at a sufficient dose suppressed platelet aggregation and showed possible add-on effects in patients with clopidogrel hyporesponsiveness.”
Add-on Antiplatelet Effects of Eicosapentaenoic Acid With Tailored Dose Setting in Patients on Dual Antiplatelet Therapy.“The EPA-AA ratio (P = .001) and ankle–brachial index (ABI: P < .001) in group A were significantly lower than those in group B. Univariate and multivariate analyses demonstrated that EPA-AA , ABI, and prescription of clopidogrel had significant correlation with PAD.”
“The lower baseline %PA may explain why the pediatric clopidogrel dose providing 30–50% IPA (0.20 mg/kg/day) is lower than a simple weight-based extrapolation of the adult dose (75 mg/day) providing similar inhibition.”
“An additional 300 mg dose of clopidogrel improves both IPA and P2Y(12) receptor occupancy mostly in the subset of 'low' responders.”
“The additional 300 mg dose of clopidogrel on top of 75 mg chronic treatment increased IPA and P2Y(12) receptor occupancy in all groups, but relatively more in low responders.”
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