Possible Interaction: Eicosapentaenoic Acid and Cisplatin

“ EPA caused 4.4%–7% proliferation of fibroblasts, but did not protect them from the toxic effect of cisplatin.”

“Conclusion: The combination of CDDP and EPA synergistically suppresses NF-κB nuclear translocation and increases apoptosis by inducing cell cycle arrest at the S or G2/M phase.”

“We previously reported a synergistic antitumor effect of cisplatin (CDDP) and EPA.”

“DHA and EPA enhanced the growth-inhibition activity of increasing concentrations of CDDP.”

“The results demonstrated synergism between CDDP and DHA or EPA in MKN45 cells.”

“PUFAs, in particular EPA and DHA, added to the cultivation medium, increased the antitumor activity of CDDP in A549 cells in a concentration dependent manner.”

“The obtained results suggest that the antiproliferative effect of CDDP in A549 cells can be enhanced by AA and in particular by EPA and DHA through their influence on autophagic and apoptotic cell death.”

“In our study, it was noted that 7-1inolenic acid (GLA) and eicosapentaenoic acid (EPA) potentiated the cytotoxicity of anticancer drugs vincristine, cis-platinum , and doxorubicin on human cervical carcinoma cells in vitro by enhancing the uptake of anticancer drugs.”

“Gamma-linolenic acid (GLA) of the n-6 series and eicosapentaenoic acid EPA ) of the n-3 series potentiated the cytotoxicity of anti-cancer drugs: vincristine, cis-platinum and doxorubicin on human cervical carcinoma (HeLa) cells in vitro.”