Possible Interaction: Eicosapentaenoic Acid and Calcium Supplement

“Conclusion: The results suggest that EPA might reduce the risk of calcium stone formation.”

“ EPA + DHA significantly increased calcium uptake capacity in both subsarcolemmal and intrafibrillar mitochondria from sham rats.”

“We previously demonstrated that sphingosylphosphorylcholine (SPC) induces Ca2+ sensitization through sequential activation of the Src family protein tyrosine kinases (Src-PTKs) and ROK in vitro, and that Ca2+ sensitization is inhibited by eicosapentaenoic acid (EPA) through the selective inactivation of Src-PTK.”

“A rapid and sustained increase in calcium was observed in mitochondria at 2 h after the addition of EPA prior to apoptosis.”

“ Eicosapentaenoic acid also decreased the amount of calcium released by thapsigargin, a drug that releases calcium from the sarcoplasmic reticulum, and decreased cation influx after angiotensin II stimulation.”

“Lipoic acid-EPA, fish oil (EPA rich) as well as the EPA monoester reduced the calcium concentration of both the kidneys and the aorta towards control values.”

“Pretreatment of the cells with eicosapentaenoic acid markedly suppressed the activation of I(Cl x Ca ) by neurokinin A or caffeine.”

“We conclude, in mice of the Swiss albino strain bearing the HSDM1 fibrosarcoma, that consumption of a diet enriched in EPA reduces the production of cyclooxygenase products of arachidonic acid metabolism and thereby reduces the elevation of plasma calcium concentration.”

“Positive inotropic effects that enhance calcium entrance through the membrane (Ca and IPA ), during action potential, increase contraction amplitude.”