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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Eicosapentaenoic Acid
drug:
Becaplermin
Research Papers that Mention the Interaction
“ EPA (10–100 µM) exhibited dose-related inhibition of PDGF-BB- and EGF-stimulated ET-1 secretion.”
“Moreover, 50 µM EPA significantly attenuated PDGF-BB- and EGF-stimulated [3H]thymidine incorporation into mesangial cells.”
“These results indicate that EPA potentially inhibits mesangial cell ET-1 production, when stimulated by PDGF-BB or EGF.”
“This inhibitory effect of EPA could be related to the attenuation of mesangial cell proliferation via inhibition of the binding of PDGF-BB or EGF to their receptors due to alteration of the physicochemical characteristics of the cell membrane.”
Eicosapentaenoic Acid Inhibits Mitogen-Induced Endothelin-1 Production and DNA Synthesis in Cultured Bovine Mesangial Cells
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