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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Eicosapentaenoic Acid
drug:
Aspirin
Research Papers that Mention the Interaction
“ EPA and DHA ingestion alone increased telomerase activity then a decrease occurred with the addition of aspirin consumption.”
The effects of aspirin and N-3 fatty acids on telomerase activity in adults with diabetes mellitus.“The non-selective COX inhibitor aspirin and the selective COX-2 inhibitor celecoxib increased sensitivity of several human and mouse CRC cell lines to EPA in vitro.”
“ Acetylsalicylic acid markedly reduced the inhibitory effects of EPA on aggregation induced by ADP and the endoperoxide analogue U46619.”
“ ASA blocks the enzyme cyclo-oxygenase-2 and thus decreases the formation proinflammatory eicosanoids, and as a result, the cellular content of precursor PUFAs (such as AA, EPA , and DHA), which have antibacterial actions, is increased.”
“In this context, it is noteworthy that ASA enhances the formation of LXA4, resolvins, and protectins from their respective precursors AA, EPA , and DHA (19).”
“The precise mechanism responsible for the combination therapy is still unknown; however, aspirin may potentiate the production of anti-inflammatory lipid mediators derived from EPA.”
“The inhibitory action of aspirin on COX-1 and COX-2 enzymes enhances the tissue concentrations of dihomo-gamma-linolenic acid (DGLA), arachidonic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).”
“Picado et al showed that a diet containing 3 g of eicosapentaenoic acid daily for six weeks worsened airflow obstruction in 10 patients with asthma and aspirin intolerance.24 These effects were attributed to inhibition of the cyclo-oxygenase pathway.”
“At the local site of inflammation, aspirin treatment enhances EPA conversion to 18R-oxygenated products, including RvE1, which carry potent antiinflammatory signals.”
Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis.“This effect was seen within 12 h and was maximal by 36 h. Aspirin blocked the induction of UCP-2 by EPA , indicating involvement of the prostaglandin pathway.”
“OBJECTIVE: In a recent study, we showed that the combination of aspirin plus the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) synergistically inhibited platelet function.”
The Effects of EPA+DHA and Aspirin on Inflammatory Cytokines and Angiogenesis Factors.
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