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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Eicosapentaenoic Acid
supplement:
Arachidonic Acid
Research Papers that Mention the Interaction
“However, in rats and humans, we have found that low doses of EPA actually elevate membrane AA phospholipid concentrations.”
Eicosapentaenoic acid and arachidonic acid: collaboration and not antagonism is the key to biological understanding.“ResultsAt fasting, there was a 2-fold higher ratio of eicosapentaenoic acid (EPA) to arachidonic acid (P = 0.046) as well as a trend towards higher relative% of EPA (P = 0.063) in the Sf >400 fraction of E4+.”
“Inclusion of 0.25 or 1 g of dietary EPA prevented the increase in plasma AA concentrations.”
“The ratio of eicosapentaenoic acid to arachidonic acid was significantly decreased at the end of 12 months’ treatment (from 0.702±0.370 to 0.541±0.204,P<0.05).”
“ Free eicosapentaenoic acid (EPA) may compete with liberated AA and result in an antiinflammatory effect.”
“A slight, but significant reduction of platelet-rich plasma aggregation in response to epinephrine and arachidonic acid occurred after EPA intake, as well as a decreased aggregation of washed platelets induced by thrombin, although collagen- and U-46619-induced aggregations were not significantly modified.”
“Although the PFO diet increased omega-3 incorporation into chondrocytes, the biological significance is unclear since concentrations of ARA were at least 9-fold higher than EPA or DHA.”
The impact of dietary long-chain polyunsaturated fatty acids on bone and cartilage in gilts and sows.“Studies into the effects of dietary fish oil showed that 2 constituents, docosahexanoic acid and eicosapentaenoic acid (EPA), inhibit the conversion of arachidonic acid by cyclo-oxygenase, but not by 5-lipoxygenase.”
“Human inflammatory cells are typically rich in the n-6 fatty acid arachidonic acid, but the contents of arachidonic acid and of the marine n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can be altered through oral administration of EPA and DHA.”
“Cells involved in the inflammatory response are typically rich in the n-6 fatty acid arachidonic acid, but the contents of arachidonic acid and of the n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can be altered through oral administration of EPA and DHA.”
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