Possible Interaction: Eicosapentaenoic Acid and Arachidonate

“ EPA acts as an alternative substrate to arachidonate , leading to the formation of the less proinflammatory prostaglandins ('3' series) and leukotrienes ('5' series).”

“In the present investigation we demonstrated that eicosapentaenoic (EPA) and docosahexaenoic acid (DCHA) the major polyunsaturated fatty acids of fish oil suppressed TxB2 formation and prevented platelet activation by AA and U46619.”

“ EPA showed a dose-dependent inhibition of platelet aggregation induced by arachidonate , epinephrine and collagen; it was most effective against AA-induced aggregation.”

“The results demonstrated that eicosapentaenoic acid in the host diet had profound effects on arachidonate assimilation by tick salivary glands, which could lead to altered prostaglandin content in tick saliva.”

“Uptake of [3H]arachidonate by isolated salivary glands was reduced in the presence of low concentrations of arachidonic or eicosapentaenoic acids , but much higher, non-physiological concentrations of oleic and linoleic acids were required to inhibit [3H]arachidonate uptake.”

“However, EPA may also affect the metabolism of arachidonate by the 5-lipoxygenase (5-LO) pathway and enhanced production of 5-LO metabolites has been implicated in the pathogenesis of kidney disease in MRL-lpr/lpr mice.”

“The fact that eicosapentaenoic acid (20:5), but not arachidic acid (20:0), mimicked the depressant effect of arachidonate on phosphoinositide labeling suggests that the degree of unsaturation of the fatty acid, rather than chain length, is important for inhibition of phosphoinositide synthesis.”