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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Eflornithine
supplement:
Tretinoin
Research Papers that Mention the Interaction
“When DFMO was given as a standard therapy, significant synergism was achieved with RA (P = 0.008).”
In vivo growth inhibition of human colon carcinoma cells (HT-29) by all-trans-retinoic acid, difluoromethylornithine, and colon mitosis inhibitor, individually and in combination.“The preliminary exposure of cultured monocytes to alpha-difluoromethylornithine (DFMO) significantly reduced TGc induction caused by RA.”
“In the presence of both RA and DFMO a mixed morphological and biochemical pattern is observed.”
“ Retinoic acid potentiated the increases in ornithine decarboxylase (L-ornithine carboxy-lyase [EC 4.1.1.17]) activity, [3H]difluoromethylornithine binding to ornithine decarboxylase, intracellular levels of polyamines and DNA synthesis in guinea pig lymphocytes stimulated with phytohemagglutinin.”
Potentiation by retinoic acid of ornithine decarboxylase induction by phytohemagglutinin or phorbol 12-myristate 13-acetate in guinea pig lymphocytes.
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