Possible Interaction: Eflornithine and S-Adenosylmethionine

“The ratio of decarboxylated S-adenosylmethionine to S-adenosyl-L-methionine increased by DFMO and decreased by spermine.”

“SummaryDepletion of the putrescine and spermidine content of Ehrlich ascites tumor cells by α-difluoromethylornithine DFMO ) treatment results in at least a 1500-fold increase in the decarboxylated S-adenosylmethionine (deSAM) content.”

“The importance of such regulation in the disposition of AdoMet can be demonstrated by inhibiting the synthesis of polyamines with a-difluoromethylornithine.”

“These studies indicate that the metabolism of AdoMet is altered significantly in DFMO refractory isolates and suggest that differences in AdoMet metabolism may be responsible for increased tolerance to DFMO.”

“Treatment with DFMO increases intracellular levels of ornithine, S-adenosylmethionine and decarboxylated S-adenosylmethionine and decreases putrescine and spermidine.”

“ DFMO treatment causes a substantial increase in the intracellular content of decarboxylated S-adenosyl-L-methionine , which was reversed by addition of putrescine.”

“Exposure to alpha-difluoromethylornithine leads to an enormous rise in the concentration of decarboxylated S-adenosylmethionine , which reached a peak at 530-fold after 3 days of exposure and steadily declined to 140-fold after 11 days.”

“Alteration of polyamine synthesis by DL-alpha-difluoromethylornithine , an enzyme-activated irreversible inhibitor of L-ornithine decarboxylase, leads to a striking accumulation of decarboxylated S-adenosyl-L-methionine in rat hepatoma cells cultured in vitro and in rat ventral prostate.”