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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Eflornithine and S-Adenosylmethionine

Research Papers that Mention the Interaction

The ratio of decarboxylated S-adenosylmethionine to S-adenosyl-L-methionine increased by DFMO and decreased by spermine.
International journal of molecular sciences  •  2019  |  View Paper
DFMO treatment caused a substantial increase in the rate of AdoMet utilization, while sinefungin extended the t1/2 and lowered AdoMet turnover.
The Biochemical journal  •  1995  |  View Paper
Treatment with DFMO increases intracellular levels of ornithine, S-adenosylmethionine and decarboxylated S-adenosylmethionine and decreases putrescine and spermidine.
Molecular and biochemical parasitology  •  1987  |  View Paper
SummaryDepletion of the putrescine and spermidine content of Ehrlich ascites tumor cells by α-difluoromethylornithine DFMO ) treatment results in at least a 1500-fold increase in the decarboxylated S-adenosylmethionine (deSAM) content.
Molecular and Cellular Biochemistry  •  1986  |  View Paper
DFMO treatment causes a substantial increase in the intracellular content of decarboxylated S-adenosyl-L-methionine , which was reversed by addition of putrescine.
European journal of cancer & clinical oncology  •  1984  |  View Paper
Exposure to alpha-difluoromethylornithine leads to an enormous rise in the concentration of decarboxylated S-adenosylmethionine , which reached a peak at 530-fold after 3 days of exposure and steadily declined to 140-fold after 11 days.
The Biochemical journal  •  1984  |  View Paper