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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Eflornithine
supplement:
Progesterone
Research Papers that Mention the Interaction
“Plasma values of progesterone and androstenedione were also decreased by DFMO treatment.”
Molecular and morphological changes in placenta and embryo development associated with the inhibition of polyamine synthesis during midpregnancy in mice.“In adult … administration of DFMO on the evening/… markedly decreased plasma progesterone levels at diestrus, which was associated to the decrease in the expression of steroidogenic factor 1, cytochrome cholesterol side … enzyme, and steroidogenic acute regulatory protein in the ovary and to a reduced vascularization of the corpora lutea.”
“In immature female mice, DFMO was found to inhibit ovarian growth, the formation of Graafian follicles, and the secretion of progesterone and estradiol.”
“The administration of the polyamine biosynthesis inhibitor alpha-difluoromethylornithine completely blocked the colony-stimulating effect of progesterone.”
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