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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Eflornithine
supplement:
Ornithine
Research Papers that Mention the Interaction
“Following a non-targeted metabolomics approach, 10 metabolites (namely, putrescine, ornithine , gamma-aminobutyric acid (GABA), oxidized and reduced glutathione, 5'-deoxy-5'-(methylthio)adenosine, N-acetylputrescine, cysteinyl-glycine, spermidine and an unknown compound) were found to be significantly altered by DFMO (p<0.05) in HT-29 cells.”
Metabolomics of adherent mammalian cells by capillary electrophoresis-mass spectrometry: HT-29 cells as case study.“Addition of 10 mM DFMO to isolated tubules dramatically decreased Orn decarboxylation in PCT and in PST.”
Ornithine decarboxylase along the mouse and rat nephron.“Pentamidine, DFMO , and alpha-monofluoromethyldehydroornithine methyl ester inhibited ornithine incorporation by up to 86% at clinically achievable concentrations.”
“ Ornithine also reversed the protection against right ventricular hypertrophy normally afforded by DFMO.”
“However, the mutant strain cultivated under DFMO for several generations has a greatly enhanced uptake of ornithine and a moderately heightened uptake of putrescine.”
“Treatment with DFMO increases intracellular levels of ornithine , S-adenosylmethionine and decarboxylated S-adenosylmethionine and decreases putrescine and spermidine.”
“Addition of 10 mM DFMO to isolated tubules dramatically decreased Orn decarboxylation in PCT and in PST.”
Ornithine decarboxylase along the mouse and rat nephron.“ alpha-Difluoromethylornithine and alpha-difluoromethylarginine inhibited ornithine and arginine decarboxylases, respectively, in all species.”
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