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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Eflornithine and Ornithine

supplement:

Ornithine

Research Papers that Mention the Interaction

Following a non-targeted metabolomics approach, 10 metabolites (namely, putrescine, ornithine , gamma-aminobutyric acid (GABA), oxidized and reduced glutathione, 5'-deoxy-5'-(methylthio)adenosine, N-acetylputrescine, cysteinyl-glycine, spermidine and an unknown compound) were found to be significantly altered by DFMO (p<0.05) in HT-29 cells.
Journal of pharmaceutical and biomedical analysis  •  2015  |  View Paper
Addition of 10 mM DFMO to isolated tubules dramatically decreased Orn decarboxylation in PCT and in PST.
The American journal of physiology  •  1998  |  View Paper
Pentamidine, DFMO , and alpha-monofluoromethyldehydroornithine methyl ester inhibited ornithine incorporation by up to 86% at clinically achievable concentrations.
The Journal of infectious diseases  •  1991  |  View Paper
Ornithine also reversed the protection against right ventricular hypertrophy normally afforded by DFMO.
Biochemical pharmacology  •  1989  |  View Paper
However, the mutant strain cultivated under DFMO for several generations has a greatly enhanced uptake of ornithine and a moderately heightened uptake of putrescine.
Molecular and biochemical parasitology  •  1987  |  View Paper
Treatment with DFMO increases intracellular levels of ornithine , S-adenosylmethionine and decarboxylated S-adenosylmethionine and decreases putrescine and spermidine.
Molecular and biochemical parasitology  •  1987  |  View Paper
Addition of 10 mM DFMO to isolated tubules dramatically decreased Orn decarboxylation in PCT and in PST.
American journal of physiology. Renal physiology  •  1998  |  View Paper
alpha-Difluoromethylornithine and alpha-difluoromethylarginine inhibited ornithine and arginine decarboxylases, respectively, in all species.
Plant physiology  •  1985  |  View Paper