Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 4 months ago

Possible Interaction: Eflornithine and Ornithine

supplement:

Ornithine

Research Papers that Mention the Interaction

The α-difluoromethyl ornithine , an irreversible inhibitor of ODC, amplified ethanol toxicity on cell viability, protein level, and DNA synthesis through accentuation of polyamine depletion in proliferating HepaRG cells.
Amino Acids  •  2012  |  View Paper
alpha-Difluoromethylornithine showed an ornithine decarboxylase inhibition of 97.1%.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies  •  1996  |  View Paper
alpha-Difluoromethylornithine and alpha-difluoromethylarginine inhibited ornithine and arginine decarboxylases, respectively, in all species.
Plant physiology  •  1985  |  View Paper
alpha-Methylornithine inhibited both ornithine decarboxylase activity and the in vivo accumulation of putrescine.
Journal of bacteriology  •  1979  |  View Paper
DFMO was observed to inhibit ornithine decarboxylase activity in JDF-1 tumors by 78%, IFN-alpha 2 by 18%, and the combination by 78%.
Cancer research  •  1984  |  View Paper
Postreceptor inhibition of the ornithine decarboxylase/polyamine cascade by alpha-difluoromethylornithine may provide neuroprotection against N-methyl-D-aspartate-induced excitotoxicity.
Journal of neurochemistry  •  1993  |  View Paper
Pentamidine, DFMO , and alpha-monofluoromethyldehydroornithine methyl ester inhibited ornithine incorporation by up to 86% at clinically achievable concentrations.
The Journal of infectious diseases  •  1991  |  View Paper
DFMO strongly inhibited DNA synthesis and proliferation of bovine pulmonary artery endothelial (BPAE) cells in culture and decreased their ornithine decarboxylase activity and intracellular polyamine concentrations.
Cancer research  •  1990  |  View Paper
Ornithine also reversed the protection against right ventricular hypertrophy normally afforded by DFMO.
Biochemical pharmacology  •  1989  |  View Paper
Treatment with DFMO increases intracellular levels of ornithine , S-adenosylmethionine and decarboxylated S-adenosylmethionine and decreases putrescine and spermidine.
Molecular and biochemical parasitology  •  1987  |  View Paper
Show More