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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Eflornithine
supplement:
Glutathione
Research Papers that Mention the Interaction
“The remaining two compounds, buthionine sulfoximine and difluoromethylornithine , are inhibitors of glutathione and polyamine synthesis, respectively, with limited intrinsic antitumor activity; however, because of their powerful biochemical actions and their low systemic toxicities, they are being evaluated as chemotherapeutic adjuncts to or modulators of other more toxic antineoplastic agents.”
Metabolism and action of amino acid analog anti-cancer agents.“Incubation of cells with DFMO for longer periods caused an increase in glutathione that is related to the depletion of polyamines and not to a decrease in growth rate or a cell cycle effect.”
Changes in the glutathione content of rat 9L cells induced by treatment with the ornithine decarboxylase inhibitor alpha-difluoromethylornithine.
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