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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Eflornithine and Arginine



Research Papers that Mention the Interaction

The flux of L-arginine through arginase in intact cells was inhibited by 51+/-11% by 10 mM of DFMO whereas 10 mM of L-valine, a known potent arginase inhibitor, inhibited this flux by 73+/-6%.
Biochemical pharmacology  •  1998  |  View Paper
In the presence of DFMO treatment, the expression of uterine iNOS and eNOS was significantly enhanced in the arginine group compared with the control group.
Reproduction  •  2013  |  View Paper
Inclusion of … decarboxylase inhibitor difluoromethylornithine in these incubations reduced the CO2 production of strain TV 10-02 by 42%, but only … the MR-100 strain by 14.5%, indicative that the majority of the CO2 liberated from arginine by this strain is derived from … elevated activity of ornithine carbamyltransferase.
Molecular and biochemical parasitology  •  1996  |  View Paper
Inhibition of polyamine biosynthesis by difluoro-methyl-ornithine completely abolished the acceleration of the healing and the increase in mucosal growth induced by L-arginine.
Digestion  •  1995  |  View Paper
They blocked arginine catabolism in their mouse AD model by administration of eflornithine (DFMO) to juvenile animals, effectively blocking the expression of AD-related amyloid pathology as the mice aged.
Front. Aging Neurosci.  •  2018  |  View Paper
The titer of polyamines in bean plants did not decline after DFMO treatment; rather, putrescine and spermidine contents actually rose, probably due to the known but paradoxical stimulation of arginine decarboxylase activity by DFMO.
Plant physiology  •  1986  |  View Paper
alpha-Difluoromethylornithine and alpha-difluoromethylarginine inhibited ornithine and arginine decarboxylases, respectively, in all species.
Plant physiology  •  1985  |  View Paper