Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Edrophonium and Tubocurarine

supplement:

Tubocurarine

Research Papers that Mention the Interaction

It is concluded that edrophonium is unreliable for antagonism of relatively deep blocks by pancuronium or tubocurarine and that neostigmine is the preferred and more reliable antagonist.
European journal of anaesthesiology  •  1987  |  View Paper
Both edrophonium and choline were more potent antagonists to paralysis by tubocurarine than could be accounted for by their ability to stimulate the motor end-plates directly.
British journal of pharmacology and chemotherapy  •  1959  |  View Paper
Conclusions Edrophonium doses that antagonize d-tubocurarine and vecuronium are less effective in antagonizing the neuromuscular effects of mivacurium during constant infusion.
Anesthesiology  •  1995  |  View Paper
Edrophonium was found to promptly antagonize the d-tubocurarine blockade.
The authors therefore conclude that edrophonium , 0.5–1.0 mg/kg, has pharmacokinetic variables comparable to neostigmine and produces prompt, sustained, and effective antagonism of d-tubocurarine neuromuscular blockade.
Anesthesiology  •  1981  |  View Paper
The enhancement of the action of d-tubocurarine was anatagonized by edrophonium and calcium.
The Japanese journal of antibiotics  •  1977  |  View Paper
The enhancement of the action of d-tubocurarine was antagonized promptly by edrophonium and more slowly by calcium.
The Tohoku journal of experimental medicine  •  1975  |  View Paper
The compounds were compared with respect to their ability to antagonize tubocurarine induced head drop in rabbits: a) Neostigmine was the most potent antagonist, … the anticurare effect of edrophonium was less than that of neostigmine and pyridostigmin, 1/12 and 1/16 respectively; and c ) intravenously administered edrophonium … tubocurarine ….
The Journal of pharmacology and experimental therapeutics  •  1957  |  View Paper
Another …, d-tubocurarine , when present … with edrophonium , increased negative ellipticity at 302 nm and blue-shifted a 265-nm peak of the normal AChE. DFP interactions with AChE … to be energetically different from those of edrophonium, the latter of which is believed to associate with the acetylcholine-binding subsite.
Biochemistry and cell biology = Biochimie et biologie cellulaire  •  1987  |  View Paper
It is also suggested that edrophonium antagonizes tubocurarine by acting as a partial agonist at the motor nerve terminal.
British journal of pharmacology  •  1972  |  View Paper
The d-tubocurarine block was potentiated by hexafluorenium and antagonized by edrophonium.
Anesthesiology  •  1965  |  View Paper
Show More