Possible Interaction: Edrophonium and Tubocurarine

“It is concluded that edrophonium is unreliable for antagonism of relatively deep blocks by pancuronium or tubocurarine and that neostigmine is the preferred and more reliable antagonist.”

“Both edrophonium and choline were more potent antagonists to paralysis by tubocurarine than could be accounted for by their ability to stimulate the motor end-plates directly.”

“Conclusions Edrophonium doses that antagonize d-tubocurarine and vecuronium are less effective in antagonizing the neuromuscular effects of mivacurium during constant infusion.”

“ Edrophonium was found to promptly antagonize the d-tubocurarine blockade.”

“The authors therefore conclude that edrophonium , 0.5–1.0 mg/kg, has pharmacokinetic variables comparable to neostigmine and produces prompt, sustained, and effective antagonism of d-tubocurarine neuromuscular blockade.”

“The enhancement of the action of d-tubocurarine was anatagonized by edrophonium and calcium.”

“The enhancement of the action of d-tubocurarine was antagonized promptly by edrophonium and more slowly by calcium.”

“The compounds were compared with respect to their ability to antagonize tubocurarine induced head drop in rabbits: a) Neostigmine was the most potent antagonist, … the anticurare effect of edrophonium was less than that of neostigmine and pyridostigmin, 1/12 and 1/16 respectively; and c ) intravenously administered edrophonium … tubocurarine ….”

“Another …, d-tubocurarine , when present … with edrophonium , increased negative ellipticity at 302 nm and blue-shifted a 265-nm peak of the normal AChE. DFP interactions with AChE … to be energetically different from those of edrophonium, the latter of which is believed to associate with the acetylcholine-binding subsite.”

“It is also suggested that edrophonium antagonizes tubocurarine by acting as a partial agonist at the motor nerve terminal.”

“The d-tubocurarine block was potentiated by hexafluorenium and antagonized by edrophonium.”