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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Edetic Acid
supplement:
Zinc Chloride
Research Papers that Mention the Interaction
“Whereas the cholinesterase activity of butyrlcholinesterase was not affected by EDTA, there was significant loss of its carboxypeptidase activity in the presence of EDTA , and the loss could be reversed by added ZnCl2.”
Evidence for a Zn(2+)-binding site in human serum butyrylcholinesterase.“A seventh peak attributable to Zn-EDTA was observed in cytosol from rats given ZnCl2 + EDTA.”
“The 65Zn level in tissues (liver, bone, muscle, skin, kidney, and thymus) of rats given ZnCl2 + EDTA was also significantly reduced compared to that of rats given ZnCl2.”
Effect of EDTA and zinc-methionine complex on zinc absorption by rat intestine.“The inhibitory effect of EDTA can be reversed with micromolar amounts of ZnCl2.”
“At 1 m m both MgCl 2 and CaCl 2 were stimulatory, whereas CuCl 2 ZnCl 2 and EDTA were inhibitors.”
“In contrast to this, the addition of EDTA to ZnCl2 reduces the intestinal Zn uptake and increases the transfer of Zn compared to ZnCl2 alone.”
“Further ZnCl2 and CoCl2 exerted protective effects on EDTA pretreated enzyme for its susceptibility to DTNB inhibition.”
Activity Staining and Inhibition Characterization of Dipeptidylpeptidase-III Enzyme from Goat Brain“The inhibition of the enzyme by EDTA was fully reversed by the addition of ZnCl2 , whereas the addition of CoCl2 activated the enzyme.”
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