Possible Interaction: Edetic Acid and Zinc Cation

“In contrast, EGTA inhibited the secretase by a maximum of 15% at a concentration of 10 mM. The inhibition of EDTA was reactivated substantially (83%) by Mg2+ ions, and partially (34% and 29%) by Zn2+ and Mn2+ ions respectively.”

“The inhibition by EDTA could be prevented by Zn2+ , but not by Ca2+ or Mg2+.”

“The protease-activity was completely inhibited in the presence of EDTA , partially inhibited by Cu2+ and Zn2+ and increased by Mn2+ (table 3).”

“The inhibition of amidolytic plasmin activity by Zn2+ and Cu2+ was reduced in the presence of EDTA , histidine, or albumin.”

“Furthermore, AMPA impaired maintained LTP and the impairment was also rescued by co-injection of CaEDTA , which blocked increase in intracellular Zn2+ , but not increase in intracellular Ca2+.”

“Moreover, the apoptosis induced by EDTA was inhibited by exogenous Zn2+.”

“In the presence of Zn2+ , the inhibitory activity of all these compounds, including EDTA , was abolished.”

“Treatment of brain membranes by EDTA resulted in loss of enzyme activity that was completely reversed by 10 microM Zn2+ , indicating that VP-AP activity is a metallopeptidase.”

“The activation of EDTA was negated by metal ions, most effectively by Se2+, Hg2+, Cu2+ and Zn2+ , and less effectively by Ca2+ and Ni2+.”

“The inhibiting effect of EDTA on the p-NPPase activity was reversed by equimolar concentrations of Zn2+.”