Possible Interaction: Edetic Acid and Tetracycline

“The 125I-LDL binding in the presence of TC was diminished by both heparin and EDTA.”

“To some extent, tetracycline inhibition of neutrophil functions is mimicked by the Ca2+ binding agents, EDTA and TMB-8.”

“On the other hand, treatment with EDTA significantly counteracted the effect of TJ-34 dried extract to reduce absorption of TC , indicating that metal ions mainly account for the interaction.”

“ TZ reduzierte die Amplitude der Herzschlage in ahnlicher Weise wie EDTA.”

“Additionally, the presence of 2-propanol and EDTA inhibited significantly the degradation of these micro-pollutants i.e., the percentage of degradation was decreased by 31.8 and 24.2% (for tetracycline ) and 42.8 and 39.9% (for sulfamethoxazole), respectively.”

“In wetland water, the addition of EDTA generally promoted the release of tetracycline indicating that a portion of the tetracycline was bound to metal ions.”

“ Tetracycline resistance was also transiently depressed by treating R-factor-bearing cells with EDTA in tris buffer.”

“The absorption of tetracycline was strongly inhibited by EDTA and ATP; ADP inhibited less strongly and AMP had no effect.”

“Weiser, Asscher and Wim-penny4 reported that EDTA increases the sensitivity of certain organisms resistant to penicillin, ampicillin, chlor-amphenicol and tetracycline presumably by overcoming their permeability barrier to these antimicrobials.”

“Abstract The disodium salt of ethylenediamine-tetra-acetic acid (E.D.T.A., edetic ) enhances the effect of penicillin G, ampicillin, tetracycline , and chloramphenicol on a resistant strain of Pseudomonas œruginosa.”