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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Edetic Acid
drug:
Sodium Fluoride
Research Papers that Mention the Interaction
“ Sodium fluoride (NaF) stimulated in vitro rat aortic prostacyclin (PGI2) synthesis (EC50 = 5 x 10(-3) mol.l-1), an action inhibited completely by the presence of EDTA (10(-2) mol.l-1).”
Fluoride stimulates in vitro vascular prostacyclin synthesis: interrelationship of G proteins and protein kinase C.“ NaF stimulated in vitro rat urinary bladder prostacyclin (PGI2) synthesis (EC50 = 6 mmol.l-1), an action inhibited by the presence of EDTA (10 mmol.l-1).”
“ Sodium fluoride strongly inhibited both reactions, and this inhibition was reversed by EDTA , while EDTA itself had no effect.”
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