Possible Interaction: Edetic Acid and Propofol

“EDTA levels increased significantly during the infusion of propofol with EDTA , reaching mean levels of 240 ng/mL. Conclusions: The results of this study indicate that propofol increases PTH levels in normal subjects; however, propofol with EDTA does not alter ionised calcium or total magnesium concentrations.”

“Measurements and Results: For the assessment of trace metals, patients receiving propofol EDTA demonstrated increased mean urinary excretion of zinc, copper, and iron compared with the normal range.”

“ EDTA and sulfite might be added as antimicrobial agents to several formulations of propofol , which may have different physiologic responses.”

“Herr et al. showed that the patients in the surgical intensive care unit receiving propofol with EDTA had significantly reduced mortality rates at 7 and 28 days compared with those receiving propofol without EDTA.”

“ EDTA and sulfite might be added as antimicrobial agents to several formulations of propofol , which may have diverse physiological reactions.”

“The administration of propofol formulations with EDTA or sodium metabisulfite may thus increase the variability of the inflammatory reaction.”

“… propofol … EDTA had significantly reduced mortality rates at 7 and 28 days compared with those receiving propofol without EDTA.2 In an animal study evaluating the … midazolam and the propofol with EDTA groups.3 They also remarked that pulmonary IL-6 can be lessened by additives in systemic anesthesia.”

“ EDTA and sulfite might be added as antimicrobial agents to several formulations of propofol , which may have different physiologic responses.”

“Herr et al. showed that the patients in the surgical intensive care unit receiving propofol with EDTA had significantly reduced mortality rates at 7 and 28 days compared with those receiving propofol without EDTA.”

“In vitro studies have confirmed that EDTA added to propofol retards microbial growth.”

“Background: It has been suggested that propofol with ethylenediaminetetraacetic acid (EDTA) can modulate the systemic inflammatory response.”

“In conclusion, (a) propofol provides neuroprotection against both in vivo and in vitro ischemic damage, and its effects are enhanced when EDTA is added; and (b) EDTA itself protects against ischemic neuronal damage, possibly, owing to its zinc-chelating action.”

“Propofol and EDTA each protected PC12 cells against oxygen—glucose deprivation-induced cell damage, and the effect of propofol was increased by adding EDTA.”

“When propofol EDTA was given intravenously 10 mins before cerebral ischemia, the zinc concentration decreased significantly in the cortical area, but not in the subcortex.”