Possible Interaction: Edetic Acid and Potassium Chloride

“In the absence of extracellular Ca, contractile responses to ACh or KCl decrease as the preincubation time or the EDTA concentration increases.”

“Prolonged incubation in the presence of EDTA (1 mmol/l) promotes a delay in the recovery of the tonic component of the contraction elicited subsequently by acetylcholine and KCl in physiological salt solution, and abolishes the phasic one.”

“Treatment of the complexes with 500 mM KCl or 500 mM KCl plus 20 mM EDTA resulted in a shift in the equilibrium density of the complexes to 1.180 and 1.176, respectively.”

“K + EDTA ) activated myosin ATPase activity was significantly higher in the KCl extract of diabetic rat platelets.”

“Another possibility is that substrate inhibition of ATPase occurs in the typo II fibres after treatment with EDTA , because the inhibition of actomyosin ATPase (0·075 molar potassium chloride.”

“It has now been confirmed by Friess and us that these opposite effects of EDTA were dependent upon the concentration of KCl.”

“Addition of A23187 plus EDTA to energized mitochondria in KCl medium determines a rapid osmotic swelling due to K+ uptake.”

“When KCl was included with the EDTA chase, a 2.4-fold increase in the turnover of the phosphoenzyme was observed.”

“When EDTA was added and KCl was depleted from the solution, the prolongation of plateau was more remarkable than when EDTA alone applied.”

“Combined therapy with potassium chloride and EDTA reduced the incidence of ventricular fibrillation to 50%.”