Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Edetic Acid and Penicillamine

supplement:

Edetic Acid

Research Papers that Mention the Interaction

Penicillamine at concentrations of 1-5 mM stimulated hyaluronic acid degradation by ferrous EDTA chelates but inhibited degradation by the XO/HX system.
Arthritis and rheumatism  •  1982  |  View Paper
EDTA inhibited the reaction by 19%, normal human serum by 23% in the average, whereas 1,10-0-phenanthroline, D-penicillamine as well as the cytostatic 5-fluorouracil resulted in nearly total inhibition.
Onkologie  •  1978  |  View Paper
Chelators such as ethylenediaminetetraacetic acid and bathocuproinedisulfonic acid were able to inhibit D-penicillamine oxidation.
Journal of inorganic biochemistry  •  2007  |  View Paper
In the previous paper on the effects of various chelating agents on the systemic action of Habu snake venom, we reported that the treatment with EDTA enhanced the toxicity of the venom while thiol-compounds such as BAL and d-penicillarnine markedly reduced it (1).
Japanese journal of pharmacology  •  1971  |  View Paper