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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Edetic Acid and NAD

supplement:

Edetic Acid

supplement:

NAD

Research Papers that Mention the Interaction

Divalent cations, preferentially Zn2+ and Mn2+, were required for the pyrophosphatase activity, since in the presence of the Zn2+ chelator TPEN (N,N,N',N'-tetrakis(2-pyridyl-methyl)ethylenediamine) or EDTA , the NAD degradation was inhibited by about 50%.
Advances in experimental medicine and biology  •  1997  |  View Paper
Inhibition of mitochondrial enzyme systems is largely prevented by added DPN , and, to a lesser degree, by EDTA.
Biochemical pharmacology  •  1960  |  View Paper
Recently it was shown that incubation of rat brush-border membrane with NAD+ resulted in release of Pi which was prevented by EDTA.
Biochimica et biophysica acta  •  1983  |  View Paper
EDTA , which prevents the release of Pi from NAD+ and which itself has no direct effect on brush-border membrane Pi transport, reverses the NAD+ inhibition of Na+-dependent Pi transport.
The Biochemical journal  •  1982  |  View Paper
NAD+ (and NADPH) activity is only slightly changed by EDTA.
Canadian journal of biochemistry  •  1971  |  View Paper