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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Edetic Acid
drug:
Meropenem
Research Papers that Mention the Interaction
“The isolates grew well in the presence of 0.4 mM EDTA which reduced the MICs of imipenem and meropenem 16and 32-fold to 0.25 and 0.06 mg/L, respectively.”
Carbapenem-hydrolysing metallo-beta-lactamases from Klebsiella pneumoniae and Escherichia coli isolated in Australia.“Enhancement of inhibition zone around imipenem and meropenem discs impregnated with EDTA as compared to those without EDTA confirmed MBL production.”
“The phenotypic susceptibility assays showed that meropenem with the addition of either EDTA , phenylboronic acid (PBA), or both, increased the zone of inhibition in comparison to meropenem alone.”
Bloodstream Infections caused by Klebsiella pneumoniae and Serratia marcescens isolates co-harboring NDM-1 and KPC-2“Cell-based NMR studies demonstrated that two known NDM-1 inhibitors, L-captopril and ethylenediaminetetraacetic acid (EDTA), inhibit the hydrolysis of meropenem in vivo.”
“All but one isolate hydrolyzed imipenem (and meropenem ), and in all cases this activity was inhibited by 1 mM EDTA.”
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