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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Edetic Acid and Meropenem

supplement:

Edetic Acid

Research Papers that Mention the Interaction

The isolates grew well in the presence of 0.4 mM EDTA which reduced the MICs of imipenem and meropenem 16and 32-fold to 0.25 and 0.06 mg/L, respectively.
Pathology  •  2004  |  View Paper
Enhancement of inhibition zone around imipenem and meropenem discs impregnated with EDTA as compared to those without EDTA confirmed MBL production.
The Indian journal of medical research  •  2008  |  View Paper
The phenotypic susceptibility assays showed that meropenem with the addition of either EDTA , phenylboronic acid (PBA), or both, increased the zone of inhibition in comparison to meropenem alone.
Annals of clinical microbiology and antimicrobials  •  2021  |  View Paper
Cell-based NMR studies demonstrated that two known NDM-1 inhibitors, L-captopril and ethylenediaminetetraacetic acid (EDTA), inhibit the hydrolysis of meropenem in vivo.
Angewandte Chemie  •  2014  |  View Paper
All but one isolate hydrolyzed imipenem (and meropenem ), and in all cases this activity was inhibited by 1 mM EDTA.
Antimicrobial Agents and Chemotherapy  •  1994  |  View Paper