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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Edetic Acid and Manganese Cation (2+)

supplement:

Edetic Acid

Research Papers that Mention the Interaction

The protease-activity was completely inhibited in the presence of EDTA , partially inhibited by Cu2+ and Zn2+ and increased by Mn2+ (table 3).
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie  •  1977  |  View Paper
The effect of Mn(II) was reversed by adding EDTA or phosphate buffer.
The Biochemical journal  •  1983  |  View Paper
EDTA is strongly inhibitory, also Zn2+ and Mn2+ (0.1 M) partially inhibit the agglutination.
Biochimica et biophysica acta  •  1978  |  View Paper
EDTA inactivates the enzyme, and activity is restored by a range of bivalent metal ions, including (in order of decreasing effectiveness) Co2+, Mn2+ , Ca2+, Mg2+, Cu2+ and Zn2+.
The Biochemical journal  •  2005  |  View Paper