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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Edetic Acid
drug:
Isoproterenol
Research Papers that Mention the Interaction
“W7, a Ca(2+)-calmodulin inhibitor and the addition of EDTA reduced the response to both platelets and isoprenaline.”
The cAMP response to isoprenaline in mononuclear cells is markedly increased in the presence of platelets.“ EDTA leads to an increase in the Vmax for adenylate cyclase activity due to all of the following agents: isoproterenol , Gpp[NH]p, forskolin and Mg2+.”
“However, EDTA is associated with enhanced sensitivity to activation by isoproterenol and increased sensitivity to the effect of Mg2+ on isoproterenol-dependent adenylate cyclase activity.”
The influence of EDTA on adenylate cyclase activity in membranes from rat and mouse myocardium.“Formation of this holocatalytic state was inhibited by conditions (4 degrees) or by compounds (e.g., GTP EDTA ) that prevented Gpp (NH) p binding or that prevented binding of isoproterenol (e.g., propranolol).”
“Noradrenaline, dopamine and isoprenaline reversed the inhibitory effect of vanadate in the presence of EDTA (0.2 mM).”
Effect of noradrenaline and vanadate on sodium, potassium-activated ATPase of human brain cortical homogenate
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