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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Edetic Acid
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“ EDTA increases iron absorption at a molar ratio EDTA: iron of less than 1:1.”
Mixture of Ferric Sodium Ethylenediaminetetraacetate (NaFeEDTA) and Ferrous Sulfate: An Effective Iron Fortificant for Complementary Foods for Young Chinese Children“Others have found that the presence of EDTA as an anticoagulant is associated with significantly lower levels of uric acid and vitamin A.3 This may be due to the potential of EDTA to act as a pro-oxidant in combination with iron."”
“As expected, EDTA strongly affects speciation analysis (especially for Fe and Zn), whereas changes due to the use of lithium-heparin (Li-He) as anticoagulant appear to be minimized.”
“Treatment with EDTA , an effective metal chelator, was explored because it can modulate free calcium and iron and prevent further free radical production.”
“Because BPDS binds Fe2+ but not Fe3+ and because only Fe2+ is transported by DMT-1, the finding that BPDS inhibited uptake from NaFeEDTA suggests that at least some iron dissociates from EDTA and is reduced just as simple inorganic iron at the brush border membrane of the enterocyte.”
“Others have found that the presence of EDTA as an anticoagulant is associated with significantly lower levels of uric acid and vitamin A.3 This may be due to the potential of EDTA to act as a pro-oxidant in combination with iron."”
“Paradoxically, when the concentration of EDTA relative to iron was equimolar or greater, the suppression of malondialdehyde formation was accompanied by the generation of hydroxyl radicals.”
“The importance of iron in the stimulation of lipid peroxidation was emphasized by the ability of Desferal* and EDTA to suppress malondialdehyde generation.”
“The addition of EDTA (ethelenediaminetetraacetic acid) allows the mobilization of iron from nonspecific macromolecular sites.”
“At a 1:1 molar ratio of EDTA to iron , absorption of non-heme iron was reduced to 72% and at a 2:1 molar ratio, to 50% of absorption without EDTA.”
“The addition of 50 mg EDTA to test meals containing 4.1 mg iron reduced absorption by approximately one-half from meals of both high (standard meal) and low (semisynthetic meal) iron availability.”
“ EDTA was added in each case to minimize interference by Fe and Mn.”
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