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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Edetic Acid
supplement:
Iodides
Research Papers that Mention the Interaction
“Ethylenediaminetetraacetic acid EDTA ) is an inhibitor of iodide (I-) oxidation that is catalyzed by horseradish peroxidase (HRP).”
Iodide oxidation and iodine reduction mediated by horseradish peroxidase in the presence of ethylenediaminetetraacetic acid (EDTA): the superoxide effect.“Both EDTA and nitrite competitively inhibit iodide oxidation, indicating that they compete with iodide for the same binding site for electron flow to the haem iron group.”
“Higher concentrations of iodide inhibit the reductase activity by EDTA.”
“ Iodide modulates the expression of the reductase activity by EDTA.”
“The data suggest that iodide competes with EDTA for compound I and modulates the iodine reductase activity by limiting the formation of the 416 nm-absorbing active compound.”
“The inhibition of iodide oxidase activity by EDTA was reversed at higher concentrations of iodide.”
“ EDTA causes a hypsochromic change in the absorption of the Soret band of HRP at 402 nm, and iodide can reverse this effect.”
“ EDTA inhibits the formation of I3- from iodide catalysed by various pure peroxidases.”
“ EDTA (4 mM) blocks the oxidation of iodide to I-3 (increase of extinction at 353 nm) by H2O2 catalyzed by horseradish peroxidase, which is reversed by the addition of an equimolar concentration of Zn2+.”
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