Possible Interaction: Edetic Acid and Insulin

“The presence of EDTA resulted unnecessary to contain the formation of the insoluble impurity, since the use of sodium citrate alone allowed to avoid this drawback.”

“Nanoparticle tracking analysis and confocal microscopy showed extensive formation of insoluble siRNA aggregates after electroporation, which could be dramatically reduced by addition of EDTA.”

“Among the excipients studied, 1mM of TETA, EDTA , or GSH prevented insulin aggregation upon metal catalyzed oxidation (MCO) for 3h at room temperature, based on size exclusion chromatography (SEC).”

“Dialysis of solubilized or purified receptors against chelating agents such as EDTA or 1, 10-phenanthroline resulted in a decrease in specific binding of insulin.”

“However, lower concentrations of EDTA (10-3 M) produced a 2-fold potentiation of the effect of insulin on the epididymal fat pad; this potentiation was observed with crystalline bovine insulin, low zinc amorphous insulin, acid-alcohol pancreatic extracts (rat), and preparations of microdissected rat islet tissue.”

“With a goosefish islet insulin preparation the EDTA potentiation was over 3-fold.”

“ Ethylenediaminetetraacetic acid samples had significantly lower insulin concentrations regardless of time and temperature (P = .001 for all comparisons).”

“Although ocular instillation of insulin alone did not decrease the serum glucose concentration, instillation of insulin with absorption promoters such as EDTA and saponin decreased it.”

“This study was conducted mainly to investigate the relative contributions of various mechanisms by which bile salts and EDTA may improve the in vitro rectal penetration of insulin in the albino rabbit.”

“Ethylenediaminetetraacetic acid (EDTA, 2 mM) significantly reduced basal and FSH-induced inhibin production, while the combined effects of EDTA and insulin on basal and FSH-induced inhibin production were additive.”

“Addition of EDTA completely diminished the stimulatory effects of insulin , ATP, and Mn2+.”