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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Edetic Acid
drug:
Hydrocortisone
Research Papers that Mention the Interaction
“CEIA cortisol results appeared to increase in the presence of excess EDTA.”
“The recommended EDTA plasma concentration of 4.1 mmol/L (1.8 mg/mL) did not alter cortisol concentrations when added to serum pools; however, the addition of ≥5.1 mmol/L (2.25 mg/mL) of EDTA increased apparent concentrations of cortisol.”
Excess EDTA interferes with cortisol measurement using a solid-phase, chemiluminescent enzyme immunoassay“Before the EDTA infusion, during the infusion and for two days thereafter, the mean plasma concentrations of cortisol were significantly higher than those from days 4 to 10 after the infusion.”
“Cortisol had no effect on cyclic AMP production in the absence of 1-24 ACTH, and cyclic AMP production was completely inhibited when 5 mM EDTA was added to the incubation tubes with the cortisol.”
“The concurrent administration of cortisol partially antagonized the degradative action of CaEDTA as evidenced by a significant reduction in urinary hydroxyproline excretion.”
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