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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Edetic Acid
supplement:
Histidine
Research Papers that Mention the Interaction
“Addition of the cell-impermeable chelator EDTA dramatically inhibited induction of strand breaks by neutrophils in complete media and prevented the enhancement of damage induced by histidine in phosphate-buffered saline.”
DNA damage induced by phorbol ester-stimulated neutrophils is augmented by extracellular cofactors. Role of histidine and metals.“EDTA was shown to act as a competitive inhibitor of cytidine 2',3'-cyclic phosphate hydrolysis by ribonuclease with a Ki … mM at pH 5.5, 25 degrees C. Molecular model building suggests that three of the four carboxyl groups of EDTA could … with histidine 12 , lysine 41 … 7.”
“ L-Histidine hydrazide (Ki = 36 mM) and imidazole (Ki = 6 mM) noncompetitively inhibited the enzyme EDTA markedly inhibited enzyme activity and this inhibition were reversed by divalent metal ions such as Mn2+, Co2+ Zn2+, Ni2+, Mg2+, and Ca2+.”
Crystalline L-histidine ammonia-lyase of Achromobacter liquidum. Crystallization and enzymic properties.
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