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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Edetic Acid
drug:
Heparin
Research Papers that Mention the Interaction
“The binding, apparently to multiple sites, was blocked by heparin and inhibited by the alpha 2MR-associated protein (alpha 2MRAP) and by EDTA.”
The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds lipoprotein lipase and beta-migrating very low density lipoprotein associated with the lipase.“ EDTA should be preferred over heparin as an additive.”
“Chelators (such as citrate or EDTA ) stand out as a unique antithrombotic alternatives to heparin as a catheter lock solution (12, 13).”
“For plasma, choline concentrations with heparin in 5 of 12 volunteers were >10% higher than with EDTA , P = 0.01.”
“[Ca(2+)](i) was lower with EDTA (122+/-11 nM) when compared with citrate and heparin (150+/-13 and 230+/-30 nM).”
“Although the agglutination is most pronounced with EDTA , it may occur with other anticoagulants as well, such as heparin , citrate or oxalate [1].”
“When heparin was used as the anticoagulant, isolation rates were low (10% to 56%, depending on the patient group); but when EDTA was used, isolation rates were much higher (50% to 100%).”
“The presence of edetic acid (EDTA) in blood samples inhibits the rise of membrane conductivity on addition of heparin.”
“This action of heparin was blocked by substances that elevate platelet cyclic AMP and by EDTA but not by inhibitors of platelet cyclooxygenase.”
“The reaction is not inhibited by heparin or citrate but is blocked by EDTA.”
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