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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Edetic Acid
Research Papers that Mention the Interaction
“Sodium deoxycholate, EDTA and bestatin significantly inhibited the posterior mucosal hydrolytic activity towards the LHRH analogues.”
The metabolic barrier of the lower intestinal tract of salmon to the oral delivery of protein and peptide drugs.“O-phenanthroline, EDTA , and thiorphan could inhibit GnRH degradation but inhibitors of post proline endopeptidase could not.”
“Co-incubation of the cells with known enzyme inhibitors including captopril (an ACE inhibitor), thiorphan (an EP24.11 inhibitor), and EDTA (an EP24.15 inhibitor) inhibited the formation of LHRH 4−10, LHRH 7−10, and LHRH 6−10 respectively.”
Enzymatic Degradation of Luteinizing Hormone Releasing Hormone (LHRH)/[D-Ala6]-LHRH in Lung Pneumocytes“ Ethylenediaminetetraacetic acid (EDTA, 5 mM), sodium deoxycholate (SDA, 10 mM) and bacitracin (3.5 or 9 mM) inhibited the degradation of LHRH in mucosal homogenates from small intestine and hindgut.”
“Under standard … 5 mM EDTA efficiently prevented the … and rat GRF for at least 3 h. Association of the ligand was time-dependent: equilibrium was reached within 30 min of … degrees C and remained stable for an additional 150 min (K1 = 5.01 +/- 0.86 nM-1.min-1).”
“Inhibition of calcium influx by omission of medium calcium and addition of 0.05 M EDTA reduced GnRH release to 50% of control.”
“ EDTA had some inhibitory effect on the action of LRF by a mechanism other than by immobilization of Ca++.”
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