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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Edetic Acid and Glutathione

supplement:

Edetic Acid

supplement:

Glutathione

Research Papers that Mention the Interaction

Ethylene diamine tetraacetic acid (EDTA) at 50 or 100 µM moderately reduced the Cu2+- or Ni2+-induced effects on GSH levels.
Drug and chemical toxicology  •  2013  |  View Paper
EDTA … glutathione (7.44 ± 0.73 µg/L, p < 0.01) compared to the basal level of 4.6 ± 0.44 µg/L. Also, the renal … than in the basal group (23.4 ± 15.81 µg/g creatinine vs 89.23 ± 58.52 µg/g creatinine, p < 0.01).
Human & experimental toxicology  •  2011  |  View Paper
EDTA and the free radical scavengers Mn(2+) and Trolox, a vitamin E analog, block the action of the endogenous AD inhibitor but not of GSSG in the presence of GSH.
Brain Research  •  1996  |  View Paper
This phenomenon may be prevented almost completely by the addition of glutathione plus EDTA.
Clinica chimica acta; international journal of clinical chemistry  •  1988  |  View Paper
In contrast to the insulin-degrading activity, which was activated by glutathione in the presence of EDTA , the peptidase activity was not affected by the thiol compound.
Biomedica biochimica acta  •  1983  |  View Paper
The combined use of EDTA and glutathione further reduced the rate to 1.6 ± 1.6 nmol/dl/week.
Therefore, the use of both glutathione and EDTA provided a 4-fold improvement over EDTA alone in protection of the plasma from lipid peroxidation.
Biochemical and biophysical research communications  •  1980  |  View Paper
Treatment with EDTA + GSH brought about the most rapid extravascular redistribution of the metal.
Pharmacology & toxicology  •  1989  |  View Paper
Here we report that the mutagenic effect of GSH can be inhibited by the use of the gamma-glutamyl-transpeptidase (gamma-GT) inhibitor anthglutin and by the metal chelators bathocuproine, EDTA and diethyldithiocarbamate.
Mutation research  •  1986  |  View Paper
Incubation of vesicles with a number of amino acids did not stimulate Pb++ uptake although two (cysteine and glutathione ) and the chelators EDTA or ethylene glycol bis(beta-aminoethyl ether)-N,N'-tetraacetic acid) completely blocked this process.
The Journal of pharmacology and experimental therapeutics  •  1984  |  View Paper
Since stimulation occurred even in the presence of EDTA, the GSH effect cannot be satisfactorily explained in terms of suppression of lipid peroxidation which is totally inhibited by EDTA.
Drug metabolism and disposition: the biological fate of chemicals  •  1983  |  View Paper
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