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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Edetic Acid
drug:
Glucagon
Research Papers that Mention the Interaction
“SummaryIn a previous report it was shown that EDTA inhibition of liver glycogen synthase phosphatase activity in preparations from normal, fed rats could be increased upon glucagon or cAMP treatment.”
The divalent cation dependence of liver glycogen synthase phosphatase activity“Perfusion with a Ca(2+)-free medium supplemented with EDTA , without previous depletion of the intracellular pools, also produced a substantial reduction in the effects of glucagon on glycolysis.”
“After extraction of cations with ethylenediamine-tetraacetic acid EDTA ), cAMP production in response to glucagon was reduced by more than 60%.”
“However, the proportion of phosphatase activity inhibited by EDTA was markedly and rapidly (15 s) increased following glucagon or cAMP administration.”
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