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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Edetic Acid
supplement:
Ferric Ion
Research Papers that Mention the Interaction
“Administered shortly after EDTA, Ca++, Mg++, Sr++, but not Fe++ , Fe+++, or Zn++ counteracted the inhibition by EDTA.”
Effects of Ethylenediaminetetraacetate and Metal Ions in Intestinal Absorption of Vitamin B12 in Man and Rats“The interaction effects of ferric ions with either visible light or EDTA were also significant on the dimerization rates.”
“The increase in immunoreactivity noted with Fe2+/Fe3+ or Mn2+ can be blocked with either EDTA or antioxidants (GSH and ascorbic acid), suggesting that it takes place during a peroxidative reaction of the lipids.”
“Stimulation of peroxidation and lysis by low levels of AH‐ was enhanced by added Fe(III) , abolished by EDTA.”
“The biosynthesis of prostaglandin H2 was promoted by ADP-Fe3+ but inhibited by EDTA and EDTA-Fe3+.”
Increased thromboxane B2 biosynthesis in platelets“In the presence of 100 microM EDTA , 5 microM Fe(III) ions nearly completely inhibited the formation of the hydroxyl radical adduct of DMPO (DMPO-OH) as well as the formation of DMPO-OOH and, when 100 microM hydrogen peroxide was present, produced DMPO-OH exclusively.”
“ EDTA in this system … potential of ferric ion and of its iron complex thereby facilitating the transfer of one electron from NADPH to tri-valent iron (more rapidly than … a flavin moiety in the reductase, but it diminishes the concentration of free iron to be required for phospholipid peroxidation.”
“In presence of Fe3+ , HL also exhibits reversible change in emission pattern with EDTA and thus offers an interesting property of molecular ‘INHIBIT’ logic gate with Fe3+ and EDTA as chemical inputs.”
A Reversible Pyrene-based Turn-on Luminescent Chemosensor for Selective Detection of Fe3+ in Aqueous Environment with Logic Gate Application“Experimental results however indicated that EDTA was also indispensable for the biological reduction of Fe(III) oxides.”
“Published experimental data on ethylenediaminetetraacetic acid (EDTA) biodegradation in the presence of ferric iron (Fe(III) ) showed that rapid biodegradation of EDTA suddenly stopped, leaving a residual of unbiodegraded EDTA that was equal to the concentration of dissolved Fe(III).”
“This analysis using CCBATCH's new sub-model for kinetically controlled complexation shows that EDTA , once it becomes complexed with Fe(III) , becomes biologically unavailable.”
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