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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Edetic Acid
supplement:
Cupric Cation
Research Papers that Mention the Interaction
“About 75% of R-(+)-HDCP were hydrolyzed after 120 min in the presence of 100 μM Cu2+ (inhibited by 5 mM EDTA).”
Albumin, the responsible protein of the Cu2+-dependent hydrolysis of O-hexyl O-2,5-dichlorophenyl phosphoramidate (HDCP) by chicken serum "antagonistic stereoselectivity".“The transition metal copper Cu(II )) further elevates ceroid accumulation and EDTA , a metal chelator, inhibits it.”
“ EDTA completely reversed the acyltransferase inhibition caused by Cu2+ or Cd2+ ions but not that caused by Hg2+ ions.”
“The protease-activity was completely inhibited in the presence of EDTA , partially inhibited by Cu2+ and Zn2+ and increased by Mn2+ (table 3).”
“The probe displayed an "on-off-on" fluorescence switch, upon the sequential addition of Cu2+ and ethylenediaminetetraacetic acid ( EDTA).”
“The Cu2+ -and Hg2+-catalyzed oxidations of HbO2 were dramatically suppressed by EDTA , while those catalyzed by Fe2+ and Fe3+ were accelerated by EDTA.”
“When 0.25 μm of EDTA was added in the presence of Cu2+ , NAC oxidation was suppressed.”
Cause of and countermeasures for oxidation of the cysteine‐derived reagent used in the amino acid derivative reactivity assay“Its activity was not inhibited by DTT and EDTA , but strongly inhibited by Cu2+ , Zn2+, and Co2+.”
“In contrast, cupric ions antagonized the inhibition of ACE activity induced by ethylenediaminetetraacetic acid , indicating that the inhibitory effect of carnosine on ACE activity is not related to the chelating action of carnosine.”
“An uptake of 1 equiv of M(II) is observed in all cases except that of Cu(II), when a second more loosely bound Cu(II) is removed by treatment with edta.”
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