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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Edetic Acid
drug:
Collagenases
Research Papers that Mention the Interaction
“Effects of collagenase were prevented by several procedures that inhibit collagenolytic activity (heating at various temperatures and incubation with metal-complexing agents such as EDTA , penicillamine and dithiothreitol).”
Haemorrhagic and inflammatory properties of collagenase fromC. histolyticum“The agglutination reaction was strongest at neutral pH and was impaired after either addition of EDTA or previous digestion of the fibrillar material by collagenase or pepsin.”
“ Collagenase B is twice as active as A on the native collagen type I. Both enzymes are inhibited by EDTA.”
“The induced collagenase cleaved native type I collagen into the 3/4 and 1/4-length fragments and showed the inhibition by ethylenediaminetetraacetic acid characteristic of the action of mammalian collagenases.”
“By analogy, it can be implied that the isolation of intestinal mononuclear cells using EDTA and collagenase may influence some of their cytotoxic activities in vitro.”
“The inhibition study with serum and EDTA suggested a minor contribution of bacterial collagenase.”
“ Collagen-peptidase activity in extracts of HeLa cells and human tumours is inactivated by Razoxane (ICRF-159), cyclophosphamide, 5-fluorouracil, thiotepa, aprotinin, EDTA and phenanthroline.”
“ EDTA , which is known to inhibit collagenases from human granulocytes, did not prevent the lysis.”
“The collagenase inhibitors sodium and calcium ethylenediaminetetraacetic acid (EDTA) probably inhibit collagenase by removing the essential calcium.”
“Like collagenase obtained from cultures of whole human skin, dermal collagenase is inhibited by human serum and EDTA.”
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